Understanding how PRMT5 modifies histones to regulate gene expression in leukemia
Official title: Molecular Basis of Histone Methylation by PRMT5
Funded at Johns Hopkins University · NIH-11053617 · Data updated 2026-11-12
This study is looking at how a protein called PRMT5 changes other proteins that help organize DNA, with the goal of finding new ways to treat acute myeloid leukemia and other cancers.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2023 |
| Project end | April 29, 2025 |
| Funding year | 2025 |
| Award (this year) | $20,675 |
| NIH project number | 5F31CA271743-03 |
| Project ID | NIH-11053617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or related hematological malignancies.
✕Less likely to help
Patients with solid tumors or those not diagnosed with acute myeloid leukemia may not benefit from this research.
What this research studies
This research investigates the role of Protein Arginine Methyltransferase 5 (PRMT5) in modifying histones, which are proteins that help package DNA in cells. By studying how PRMT5 interacts with histones and the effects of these modifications on gene expression, the research aims to uncover mechanisms that could lead to new treatments for acute myeloid leukemia and other cancers. The approach involves biochemical assays and molecular biology techniques to analyze the methylation process and its implications for cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating acute myeloid leukemia by targeting the mechanisms of gene regulation.
How similar studies have gone: Previous research has shown that targeting histone modifications can be effective in treating various cancers, suggesting a promising avenue for this approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Rahman, Sanim — Johns Hopkins University
- Study coordinator: Rahman, Sanim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.