Understanding how post-TB lung disease develops after TB in rural Uganda
Official title: Causality of Post-TB Lung Disease: Population-Level Evidence from Rural Uganda
Funded at Johns Hopkins University · NIH-11609909 · Data updated 2026-11-12
This grant aims to study how lung problems after TB arise and who is most at risk, using data from a large cohort in rural Uganda.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 12, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $730,562 |
| NIH project number | 3R01AI186761-02S1 |
| Project ID | NIH-11609909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in rural Uganda who are at risk for TB and can commit to a long-term follow-up.
✕Less likely to help
People who do not develop TB or who cannot participate in long-term follow-up may not benefit.
What this research studies
Researchers will follow a prospective group of about 9,000 adults in rural Uganda to measure lung function and symptoms before and after TB develops. The study will compare how pre-existing factors like smoking and prior lung damage influence post-TB lung disease versus damage caused by TB itself. By tracking participants over time, the project hopes to identify opportunities to prevent PTLD through better TB control, earlier diagnosis, or risk-factor modification. The findings could help tailor interventions for people living with TB or at risk of TB in similar settings.
Why it matters
Potential benefit: If successful, the project could inform strategies to prevent or lessen post-TB lung disease and reduce mortality among TB survivors.
How similar studies have gone: This approach builds on prior work showing that lung health trajectories before and after TB influence PTLD, with potential for new, context-specific insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Dowdy, David Wesley — Johns Hopkins University
- Study coordinator: Dowdy, David Wesley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.