Understanding how Polycomb complexes regulate gene silencing during development
Official title: Repressive Heterochromatin Establishment by Polycomb Complexes
Funded at University of Pennsylvania · NIH-10996853 · Data updated 2026-11-12
This study is looking at how certain protein complexes help control gene activity during early development, which could help us understand genetic issues related to conditions like microcephaly and Weaver syndrome, ultimately aiming to improve diagnosis and treatment for those affected.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM156018-01 |
| Project ID | NIH-10996853 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental disorders such as microcephaly or Weaver syndrome, or those with a family history of these conditions.
✕Less likely to help
Patients with unrelated genetic disorders or those not affected by neurodevelopmental issues may not receive any benefit from this research.
What this research studies
This research investigates the roles of Polycomb Repressive Complexes 1 and 2 in controlling gene expression during early development. By examining how these complexes modify chromatin structure and influence gene silencing, the study aims to uncover the mechanisms behind neurodevelopmental disorders linked to mutations in these complexes. Patients may benefit from insights gained about the genetic factors involved in conditions like microcephaly and Weaver syndrome, potentially leading to improved diagnostic and therapeutic strategies. The research employs advanced molecular biology techniques to analyze gene regulation in various cell types.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurodevelopmental disorders associated with Polycomb complex mutations.
How similar studies have gone: Previous research has shown promising results in understanding the functions of Polycomb complexes, indicating that this approach has the potential for significant advancements in the field.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Garcia, Segovia — University of Pennsylvania
- Study coordinator: Garcia, Segovia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.