Understanding how pediatric intestinal failure develops over time
Official title: Defining pediatric intestinal failure natural history
Funded at University of Pittsburgh at Pittsburgh · NIH-11034310 · Data updated 2026-11-12
This study is looking at how intestinal failure in children develops over time to find better treatments for kids who need special nutrition to grow and thrive.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 5, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,515,663 |
| NIH project number | 1R01FD007597-01A1 |
| Project ID | NIH-11034310 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with pediatric intestinal failure, including those with short bowel syndrome and functional intestinal failure.
✕Less likely to help
Patients with other gastrointestinal disorders that do not involve intestinal failure may not benefit from this research.
What this research studies
This research investigates the natural history of pediatric intestinal failure (IF), a rare condition affecting children who rely on parenteral nutrition for growth and development. The study aims to gather high-quality data on the progression of IF, which can be classified into short bowel syndrome and functional intestinal failure. By understanding how these conditions evolve, the research seeks to identify potential therapeutic targets and improve treatment options for affected children. The findings could help inform clinical trials and drug development for this underserved population.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options and improved outcomes for children with intestinal failure.
How similar studies have gone: While research on pediatric intestinal failure is limited due to its rarity, similar studies in other rare conditions have shown that understanding natural history can lead to significant advancements in treatment.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Horslen, Simon — University of Pittsburgh at Pittsburgh
- Study coordinator: Horslen, Simon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.