Understanding how our body's internal clock affects gene regulation.
Official title: Investigating Circadian Post-Transcriptional Regulation.
Funded at Rensselaer Polytechnic Institute · NIH-10901841 · Data updated 2026-11-12
This study is looking at how our body's internal clock affects our health, especially our immune system, and aims to find out how changes in this clock can influence how our genes work, which could help us better understand and manage health issues related to these disruptions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | August 15, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $423,398 |
| NIH project number | 5R35GM128687-07 |
| Project ID | NIH-10901841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing health issues related to circadian rhythm disruptions, such as sleep disorders or metabolic conditions.
✕Less likely to help
Patients with stable circadian rhythms and no related health issues may not benefit from this research.
What this research studies
This research investigates the mechanisms by which our circadian rhythms, or internal biological clocks, regulate cellular functions and gene expression. It focuses on how disruptions in these rhythms can impact health, particularly in relation to the immune system. The study aims to uncover the post-transcriptional processes that influence how genes are expressed in a time-dependent manner, which could lead to new insights into managing health conditions linked to circadian dysregulation.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to circadian rhythm disruptions, enhancing overall health and well-being.
How similar studies have gone: Other research has shown promising results in understanding circadian rhythms and their impact on health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Hurley, Jennifer Marie — Rensselaer Polytechnic Institute
- Study coordinator: Hurley, Jennifer Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.