Circadian Control of Immune Timing in Human Health
Official title: Investigating Circadian Post-Transcriptional Regulation.
Funded at Rensselaer Polytechnic Institute · NIH-11381805 · Data updated 2026-11-12
A scientifically focused project aims to understand how the body’s daily clock influences immune responses and metabolism at the cellular level.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | August 15, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $423,398 |
| NIH project number | 5R35GM128687-09 |
| Project ID | NIH-11381805 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with cancer or disorders where circadian disruption affects health may benefit from insights into clock-driven biology and potential future therapies.
✕Less likely to help
The grant is primarily basic science; immediate patient benefits may be indirect and require further development.
What this research studies
This research looks at how 24-hour biological rhythms regulate cells and tissues, with a focus on how timing affects immune function and metabolism. It explores why disruption of circadian timing can lead to poorer long-term health and diseases such as cancer. The team will study non-transcriptional ways the clock influences biology, including protein interactions and biophysical processes, to better understand clock-driven changes in the immune system. The work combines molecular, cellular, and physiological approaches to map how timing affects disease-related pathways.
Why it matters
Potential benefit: If successful, the project could reveal new targets to optimize treatments by aligning them with the body’s clock, potentially improving outcomes for patients with cancer.
How similar studies have gone: Previous work shows circadian biology influences immune and metabolic processes, with emerging evidence of post-transcriptional clock control.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Hurley, Jennifer Marie — Rensselaer Polytechnic Institute
- Study coordinator: Hurley, Jennifer Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.