Understanding how osteoblast development affects Osteogenesis Imperfecta Type V
Official title: INVESTIGATING THE CONTRIBUTION OF OSTEOBLAST DIFFERENTIATION IN THE PATHOGENESIS OF OSTEOGENESIS IMPERFECTA TYPE V
Funded at Baylor College of Medicine · NIH-11070589 · Data updated 2026-11-12
This study is looking at how a specific genetic change affects bone-building cells in people with Osteogenesis Imperfecta Type V, with the hope of finding better treatments to help strengthen their bones.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 1F30HD117560-01 |
| Project ID | NIH-11070589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Osteogenesis Imperfecta Type V, particularly those with the specific genetic mutation being studied.
✕Less likely to help
Patients with other types of Osteogenesis Imperfecta or those without the specific genetic mutation associated with OI-V may not benefit from this research.
What this research studies
This research investigates the role of osteoblast differentiation in Osteogenesis Imperfecta Type V (OI-V), a genetic condition that leads to fragile bones. The study focuses on a specific genetic mutation that alters the function of a protein involved in bone formation. By exploring how this mutation affects osteoblasts, the research aims to identify new therapeutic approaches that could improve treatment outcomes for patients with OI-V. The ultimate goal is to develop targeted therapies that address the unique challenges faced by these patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Osteogenesis Imperfecta Type V, improving bone health and reducing fractures in affected patients.
How similar studies have gone: Previous research has shown promise in understanding genetic contributions to Osteogenesis Imperfecta, but this specific approach to OI-V is relatively novel.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Busse, Emily — Baylor College of Medicine
- Study coordinator: Busse, Emily
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.