Understanding how nutrient transporters affect cell growth in diseases
Official title: Substrate Specificity Determinants in Nutrient Solute Carrier Transporters
Funded at Icahn School of Medicine at Mount Sinai · NIH-10885212 · Data updated 2026-11-12
This study is looking at how certain proteins that help move amino acids into cells can affect cell growth, especially in conditions like cancer and autoimmune diseases, with the hope of finding new ways to improve treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $402,346 |
| NIH project number | 5R01CA277794-11 |
| Project ID | NIH-10885212 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancer, autoimmune diseases, or conditions related to altered cell metabolism.
✕Less likely to help
Patients with stable metabolic conditions or those not affected by the diseases being studied may not benefit from this research.
What this research studies
This research investigates how specific nutrient transporters in cells contribute to the metabolism of amino acids, which is crucial for the growth of cells in conditions like cancer and autoimmune diseases. By using advanced computational methods alongside biochemical and biophysical techniques, the team aims to characterize two key amino acid transporters that influence cellular metabolism. The goal is to identify how these transporters can be modulated to potentially improve treatment strategies for rapidly growing cells in various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target nutrient transporters to inhibit the growth of cancerous and diseased cells.
How similar studies have gone: Previous research has shown promise in targeting nutrient transporters for therapeutic purposes, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Schlessinger, Avner — Icahn School of Medicine at Mount Sinai
- Study coordinator: Schlessinger, Avner
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.