Understanding how nutrient transporters affect cell growth in diseases
Substrate Specificity Determinants in Nutrient Solute Carrier Transporters
This study is looking at how certain proteins that help move amino acids into cells can affect cell growth, especially in conditions like cancer and autoimmune diseases, with the hope of finding new ways to improve treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10885212 on NIH RePORTER |
What this research studies
This research investigates how specific nutrient transporters in cells contribute to the metabolism of amino acids, which is crucial for the growth of cells in conditions like cancer and autoimmune diseases. By using advanced computational methods alongside biochemical and biophysical techniques, the team aims to characterize two key amino acid transporters that influence cellular metabolism. The goal is to identify how these transporters can be modulated to potentially improve treatment strategies for rapidly growing cells in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancer, autoimmune diseases, or conditions related to altered cell metabolism.
Not a fit: Patients with stable metabolic conditions or those not affected by the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target nutrient transporters to inhibit the growth of cancerous and diseased cells.
How similar studies have performed: Previous research has shown promise in targeting nutrient transporters for therapeutic purposes, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Schlessinger, Avner — Icahn School of Medicine at Mount Sinai
- Study coordinator: Schlessinger, Avner
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.