Understanding how neural circuits control working memory and decisions
Official title: Mechanisms of neural circuit dynamics in working memory and decision-making
Funded at Princeton University · NIH-11385500 · Data updated 2026-11-12
A large NIH grant is exploring how brain circuits work together to support thinking and memory, with potential implications for Alzheimer’s-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $4,189,593 |
| NIH project number | 5U19NS132720-04 |
| Project ID | NIH-11385500 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease dementia or related cognitive disorders may benefit from advances arising from this research.
✕Less likely to help
This core Administrative Core does not directly test patients but enables research that could lead to patient-focused outcomes.
What this research studies
This project supports multiple studies that examine how neural networks govern working memory and decision-making. A central Administrative Core coordinates teams, budgets, and regulatory tasks to keep researchers aligned and productive. The program builds on years of collaboration to translate basic circuit findings into insights that could help people affected by Alzheimer’s disease and related conditions. Participants would be involved through future studies that stem from these core discoveries and potentially contribute data or samples as the research progresses. The grant emphasizes team planning, oversight, and coordination to accelerate meaningful discoveries for patients.
Why it matters
Potential benefit: If successful, findings could improve our understanding of memory and decision processes in Alzheimer’s-related conditions, guiding future therapies.
How similar studies have gone: Past multi-project NIH collaborations have yielded meaningful advances in understanding brain circuits and memory.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Brody, Carlos D — Princeton University
- Study coordinator: Brody, Carlos D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.