Understanding how mixed drug use affects overdose prevention
Official title: RFA-CE-22-011: Mixed methods study of polysubstance use to optimize overdose prevention
Funded at Johns Hopkins University · NIH-10833992 · Data updated 2026-11-12
This study is looking at how people who use both opioids and stimulants can stay safer and avoid overdoses, and it’s for anyone who has experience with using multiple substances and wants to share their story to help find better prevention strategies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $349,999 |
| NIH project number | 5R01CE003467-03 |
| Project ID | NIH-10833992 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who engage in polysubstance use, particularly those using combinations of opioids and stimulants.
✕Less likely to help
Patients who only use a single substance or do not engage in drug use may not benefit from this research.
What this research studies
This research investigates the patterns and risks associated with polysubstance use, particularly focusing on the combination of opioids and stimulants, which has been linked to a significant number of overdose deaths. By utilizing a mixed methods approach, the study will analyze behavioral data and conduct qualitative interviews to understand the experiences of individuals who use multiple substances. The goal is to identify effective strategies for overdose prevention tailored to the complexities of polysubstance use. Participants will contribute to a deeper understanding of how their drug use patterns evolve over time and the factors that influence their risk of overdose.
Why it matters
Potential benefit: If successful, this research could lead to improved overdose prevention strategies that are specifically designed for individuals who use multiple substances.
How similar studies have gone: Previous research has shown that understanding the complexities of drug use patterns can lead to more effective prevention strategies, indicating that this approach has potential for success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: German, Danielle — Johns Hopkins University
- Study coordinator: German, Danielle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.