Understanding how mixed drug use affects overdose prevention

RFA-CE-22-011: Mixed methods study of polysubstance use to optimize overdose prevention

NIH-funded research Johns Hopkins University · NIH-10833992

This study is looking at how people who use both opioids and stimulants can stay safer and avoid overdoses, and it’s for anyone who has experience with using multiple substances and wants to share their story to help find better prevention strategies.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-10833992 on NIH RePORTER

What this research studies

This research investigates the patterns and risks associated with polysubstance use, particularly focusing on the combination of opioids and stimulants, which has been linked to a significant number of overdose deaths. By utilizing a mixed methods approach, the study will analyze behavioral data and conduct qualitative interviews to understand the experiences of individuals who use multiple substances. The goal is to identify effective strategies for overdose prevention tailored to the complexities of polysubstance use. Participants will contribute to a deeper understanding of how their drug use patterns evolve over time and the factors that influence their risk of overdose.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who engage in polysubstance use, particularly those using combinations of opioids and stimulants.

Not a fit: Patients who only use a single substance or do not engage in drug use may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved overdose prevention strategies that are specifically designed for individuals who use multiple substances.

How similar studies have performed: Previous research has shown that understanding the complexities of drug use patterns can lead to more effective prevention strategies, indicating that this approach has potential for success.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.