Understanding how mitochondrial and autophagy dysfunction affects inflammation in age-related macular degeneration.
Official title: Deciphering the role of mitochondrial/autophagy dysfunction in regulating inflammatory processes during AMD pathogenesis
Funded at Johns Hopkins University · NIH-11171968 · Data updated 2026-11-12
This study is looking at how inflammation affects vision in older adults with age-related macular degeneration (AMD) and aims to understand how certain cellular processes might contribute to this problem, which could help find new ways to treat the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $92,707 |
| NIH project number | 7K99EY033421-02 |
| Project ID | NIH-11171968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals diagnosed with dry age-related macular degeneration.
✕Less likely to help
Patients with other forms of macular degeneration or those without any retinal diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms behind inflammation in age-related macular degeneration (AMD), a leading cause of blindness in older adults. It focuses on how dysfunction in mitochondrial processes and autophagy may contribute to chronic inflammation that damages retinal cells. By studying both human patients and mouse models, the research aims to uncover the role of specific signaling pathways, particularly the Akt2 pathway, in the progression of AMD. The findings could lead to new insights into potential therapeutic targets for managing this condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that mitigate inflammation and slow the progression of age-related macular degeneration.
How similar studies have gone: Previous research has shown promising results in understanding inflammation's role in AMD, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Ghosh, Sayan — Johns Hopkins University
- Study coordinator: Ghosh, Sayan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.