Understanding how mitochondria function in rod photoreceptor cells
Role of mitochondrial dynamics in rod photoreceptor cells
This study is looking at how the tiny energy factories in our eye cells, called mitochondria, change shape and function, and how these changes can affect our vision, especially in people with eye conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10940463 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondria, the energy-producing structures in cells, specifically in rod photoreceptor cells of the retina. It aims to understand how the dynamic changes in the shape and function of mitochondria affect the health and function of these cells, which are crucial for vision. The study will involve examining the effects of specific proteins that control mitochondrial fusion and fission, and how their absence leads to cell degeneration over time. By using a model that mimics human conditions, the research seeks to uncover the relationship between mitochondrial dynamics and retinal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with retinal degeneration or those at risk of developing retinal diseases, particularly adults.
Not a fit: Patients with non-retinal related conditions or those who do not have any mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for retinal diseases that affect vision.
How similar studies have performed: Previous research has shown that understanding mitochondrial dynamics can lead to significant advancements in treating various cellular dysfunctions, suggesting a promising avenue for this investigation.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Ikeda, Akihiro — University of Wisconsin-Madison
- Study coordinator: Ikeda, Akihiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.