Understanding how mitochondria function in rod photoreceptor cells
Official title: Role of mitochondrial dynamics in rod photoreceptor cells
Funded at University of Wisconsin-Madison · NIH-10940463 · Data updated 2026-11-12
This study is looking at how the tiny energy factories in our eye cells, called mitochondria, change shape and function, and how these changes can affect our vision, especially in people with eye conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $388,750 |
| NIH project number | 1R01EY036383-01 |
| Project ID | NIH-10940463 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with retinal degeneration or those at risk of developing retinal diseases, particularly adults.
✕Less likely to help
Patients with non-retinal related conditions or those who do not have any mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of mitochondria, the energy-producing structures in cells, specifically in rod photoreceptor cells of the retina. It aims to understand how the dynamic changes in the shape and function of mitochondria affect the health and function of these cells, which are crucial for vision. The study will involve examining the effects of specific proteins that control mitochondrial fusion and fission, and how their absence leads to cell degeneration over time. By using a model that mimics human conditions, the research seeks to uncover the relationship between mitochondrial dynamics and retinal health.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for retinal diseases that affect vision.
How similar studies have gone: Previous research has shown that understanding mitochondrial dynamics can lead to significant advancements in treating various cellular dysfunctions, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Ikeda, Akihiro — University of Wisconsin-Madison
- Study coordinator: Ikeda, Akihiro
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.