Understanding how miR-718 affects genes and cell changes
In Vitro Identification of miR-718 targets and miR-718-induced epigenetic modifications
This project explores how a tiny molecule called miR-718 changes gene activity in human cells, which could be important for understanding diseases like cancer and heart conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina NIH-funded |
| Lab location | 1 site (Spartanburg, United States) |
| Project ID | NIH-11161609 on NIH RePORTER |
What this research studies
Our bodies have tiny molecules called microRNAs that can turn genes on or off without changing our DNA. This project focuses on one specific microRNA, miR-718, which we know very little about. We are working with human cells in the lab to discover which genes miR-718 controls and how it causes changes in these genes. By understanding these basic processes, we hope to uncover new ways that diseases develop.
Who could benefit from this research
Good fit: This foundational laboratory work does not directly involve patients, but future studies building on these findings may seek individuals with cancers, cardiovascular disease, or neurological disorders.
Not a fit: Patients not affected by cancers, cardiovascular disease, or neurological disorders would not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could reveal new targets for future medicines aimed at treating cancers, cardiovascular disease, and neurological disorders by adjusting miR-718 activity.
How similar studies have performed: Research on miR-718 is currently limited, making this a novel and foundational exploration into its mechanisms.
Where this research is happening
Spartanburg, United States
- University of South Carolina — Spartanburg, United States (Active)
Researchers
- Principal investigator: Shorter, Kimberly R — University of South Carolina
- Study coordinator: Shorter, Kimberly R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.