Investigating how a viral protein interacts with host RNA in SARS-CoV
Official title: Exploring the dynamics of nsp1 and RNA interaction in SARS-CoV with undergraduate researchers
Funded at University of South Carolina · NIH-10730676 · Data updated 2026-11-12
This study is looking at how a specific protein from the SARS coronavirus helps the virus thrive by targeting certain parts of our cells while leaving its own RNA safe, and it's a great chance for students to learn while helping us understand more about how the virus works.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina NIH-funded |
| Lab location | 1 site (Spartanburg, United States) |
| Project start | June 3, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $406,504 |
| NIH project number | 1R15AI178603-01 |
| Project ID | NIH-10730676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by SARS-CoV infections, including those with COVID-19 or related respiratory illnesses.
✕Less likely to help
Patients who are not infected with SARS-CoV or do not have related conditions may not benefit from this research.
What this research studies
This research focuses on understanding how the nonstructural protein 1 (nsp1) of SARS coronaviruses selectively targets host mRNAs while sparing viral RNA. By examining the interactions between nsp1 and specific RNA sequences, the study aims to uncover the mechanisms that allow the virus to hijack cellular machinery for its propagation. The research involves detailed analysis of protein and RNA compositions in stress granules to determine how viral RNA is protected from degradation. This work is conducted with the involvement of undergraduate researchers, providing a unique educational opportunity while advancing our knowledge of viral behavior.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that specifically target the mechanisms used by SARS-CoV to evade host defenses.
How similar studies have gone: Previous research has shown promising results in understanding viral-host interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of South Carolina
Spartanburg, United States Active
Researchers
- Principal investigator: Nag, Anita — University of South Carolina
- Study coordinator: Nag, Anita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.