Identifying targets of a specific microRNA involved in diseases
Official title: In Vitro Identification of miR-718 targets and miR-718-induced epigenetic modifications
Funded at University of South Carolina · NIH-10937142 · Data updated 2026-11-12
This study is looking at a tiny molecule called miR-718 to see how it might affect important processes in brain cells that could be linked to diseases like cancer and heart problems, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina NIH-funded |
| Lab location | 1 site (Spartanburg, United States) |
| Project start | August 5, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $172,500 |
| NIH project number | 1R16GM154787-01 |
| Project ID | NIH-10937142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or cardiovascular diseases who may benefit from novel therapeutic approaches targeting miR-718.
✕Less likely to help
Patients with conditions unrelated to the pathways influenced by miR-718 may not receive any benefit from this research.
What this research studies
This research investigates the role of miR-718, a microRNA that may influence gene expression related to various diseases, including cancers and cardiovascular conditions. By using a human neuronal model, the study aims to understand how miR-718 affects important cellular pathways such as apoptosis and calcium signaling. The researchers will analyze the effects of miR-718 on specific genes that are known to be involved in these processes, which could lead to new insights into disease mechanisms and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers and cardiovascular diseases by targeting miR-718 and its associated pathways.
How similar studies have gone: While the specific focus on miR-718 is relatively novel, similar research on other microRNAs has shown promising results in understanding disease mechanisms and developing targeted therapies.
Where this research is happening
-
University of South Carolina
Spartanburg, United States Active
Researchers
- Principal investigator: Shorter, Kimberly R — University of South Carolina
- Study coordinator: Shorter, Kimberly R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.