Understanding how metabolism affects immune cell function
Official title: Exploring metabolic governance of immune cell form and function
Funded at Icahn School of Medicine at Mount Sinai · NIH-10901981 · Data updated 2026-11-12
This study is looking at how certain metabolic processes help immune cells called tissue-resident macrophages (TRMs) do their job in different parts of the body, which could help us understand how these cells keep our tissues healthy or contribute to disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $506,488 |
| NIH project number | 5DP2AI177905-02 |
| Project ID | NIH-10901981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who may have conditions affecting immune function or tissue health.
✕Less likely to help
Patients with acute infections or those who are not over 21 years old may not benefit from this research.
What this research studies
This research investigates the metabolic factors that are crucial for the development and function of tissue-resident macrophages (TRMs), which are immune cells that reside in tissues. By utilizing advanced metabolomics technology, the study aims to explore how these cells use metabolism to maintain their specific roles within tissues. The approach includes using metabolic tracers and innovative techniques to isolate TRMs from tissues, allowing researchers to identify essential metabolic programs that support TRM function. This research could lead to a deeper understanding of how immune cells contribute to tissue health and disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune cell behavior, potentially leading to new therapies for diseases involving immune dysfunction.
How similar studies have gone: Other research has shown promise in understanding immune cell metabolism, but this specific approach focusing on TRMs is relatively novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Puleston, Daniel — Icahn School of Medicine at Mount Sinai
- Study coordinator: Puleston, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.