Understanding how metabolic issues affect multiple organ dysfunction in children with mitochondrial disorders
Official title: Metabolic regulation of MODS in pediatric mitochondrial disorders
Funded at University of Arkansas at Fayetteville · NIH-11095990 · Data updated 2026-11-12
This study is looking at how problems with tiny energy factories in cells, called mitochondria, can cause serious issues in different organs of children with specific mitochondrial disorders, and it aims to find out how certain substances in the body might be making things worse, so we can improve care for these kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $613,390 |
| NIH project number | 5R01HD110536-03 |
| Project ID | NIH-11095990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with primary mitochondrial disorders, particularly those experiencing multiple organ dysfunction.
✕Less likely to help
Patients with mitochondrial disorders who do not exhibit multiple organ dysfunction may not benefit from this research.
What this research studies
This research investigates the complex mechanisms behind mitochondrial-induced multiple organ dysfunction syndrome (MIMODS) in children with primary mitochondrial disorders. By examining tissue-specific mitochondrial dysfunction and its effects on various organs, the study aims to identify how elevated levels of certain metabolites, like putrescine, contribute to oxidative stress and organ failure. The research involves analyzing pediatric fibroblast samples to understand the underlying bioenergetic health and mitochondrial morphology. Through advanced techniques such as next-generation sequencing and metabolite profiling, the team seeks to uncover critical insights that could lead to better management of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for children suffering from mitochondrial disorders and related organ dysfunction.
How similar studies have gone: While research on mitochondrial disorders is ongoing, this specific approach to understanding MIMODS through metabolic regulation is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Iyer, Shilpa — University of Arkansas at Fayetteville
- Study coordinator: Iyer, Shilpa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.