Transforming Spatial Proteomics for Nanometer-Scale Protein Mapping
Official title: Transforming Spatial Proteomics via Simultaneous Multiplexed Imaging at Single-Protein Resolution
Funded at University of Arkansas at Fayetteville · NIH-11429280 · Data updated 2026-11-12
A research project aims to map where proteins are and how they interact inside cells at incredibly tiny scales to better understand cancer biology.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | September 1, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $400,499 |
| NIH project number | 1R35GM166435-01 |
| Project ID | NIH-11429280 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancer or cancer predisposition whose tissues could be studied or used to develop better mapping methods.
✕Less likely to help
This project focuses on method development; direct patient benefits will depend on downstream applications.
What this research studies
This project combines advanced imaging techniques to map hundreds of proteins at single-molecule resolution, revealing how proteins are organized within cancer-related tissues. It introduces Simul-Proteomics, a high-throughput platform that uses spectral phasor analysis, engineered probes, and light sheet illumination to overcome current limits. The goal is to see nanoscale protein assemblies directly, which could illuminate new targets and mechanisms in cancer biology.
Why it matters
Potential benefit: If successful, patients could benefit from deeper insights into cancer biology that may lead to new diagnostics or therapies.
How similar studies have gone: Prior imaging-based approaches have advanced spatial proteomics, but the proposed method promises higher resolution and throughput.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Dong, Bin — University of Arkansas at Fayetteville
- Study coordinator: Dong, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.