Understanding how mechanical forces affect immune cell behavior
Official title: Establishing an immune mechanome
Funded at University of Notre Dame · NIH-11169609 · Data updated 2026-11-12
This study is looking at how the physical forces in our body tissues affect immune cells, which are important for fighting inflammation and diseases, to help find new ways to improve treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $69,550 |
| NIH project number | 3R35GM151041-02S1 |
| Project ID | NIH-11169609 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve inflammation or immune system dysfunction.
✕Less likely to help
Patients with stable, non-inflammatory conditions may not receive direct benefits from this research.
What this research studies
This research investigates how mechanical forces in tissues influence the behavior of immune cells, which play a crucial role in inflammation and disease progression. By using advanced engineering tools and imaging techniques, the study aims to explore how these forces affect immune cell movement, interactions, and functions in various organs. The research will involve both in vivo and ex vivo experiments to gain insights into the immune response under different mechanical conditions, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases where immune response and mechanical forces are involved.
How similar studies have gone: While the specific approach of studying the immune mechanome is novel, related research has shown that understanding mechanical forces can significantly impact immune responses.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: Datta, Meenal — University of Notre Dame
- Study coordinator: Datta, Meenal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.