Understanding how malaria parasites interact with host cells
Official title: UIS2 function in establishing transport mechanisms at the malaria parasite-host cell interface
Funded at Iowa State University · NIH-10738791 · Data updated 2026-11-12
This study is looking at how malaria parasites use a special protein to help them get what they need from red blood cells, with the goal of finding new ways to treat malaria, especially when current medicines aren't working well.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Iowa State University NIH-funded |
| Lab location | 1 site (Ames, United States) |
| Project start | November 10, 2022 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $186,642 |
| NIH project number | 5R21AI173810-02 |
| Project ID | NIH-10738791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions, particularly those who have experienced drug-resistant malaria infections.
✕Less likely to help
Patients who do not have malaria or are not at risk of malaria infection may not benefit from this research.
What this research studies
This research investigates the mechanisms by which malaria parasites establish transport systems within host red blood cells. It focuses on a specific protein, UIS2, which is believed to play a crucial role in the functioning of another protein, EXP2, that allows the parasite to export necessary proteins and nutrients. By studying these interactions, the research aims to uncover new therapeutic targets that could lead to more effective treatments for malaria, especially in cases where drug resistance is a concern.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel anti-malarial therapies that are effective against drug-resistant strains of malaria.
How similar studies have gone: Other research has shown promise in targeting similar mechanisms in malaria parasites, indicating that this approach could yield significant advancements in treatment.
Where this research is happening
-
Iowa State University
Ames, United States Active
Researchers
- Principal investigator: Beck, Josh Ryan — Iowa State University
- Study coordinator: Beck, Josh Ryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.