Understanding how lysosomes repair themselves through lipid changes
Official title: Lysosomal quality control through lipid remodeling
Funded at University of Pittsburgh at Pittsburgh · NIH-11035481 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called lysosomes help keep our cells healthy by recycling nutrients and dealing with stress, especially as we age or face heart problems, and it aims to find new ways to help these lysosomes fix themselves faster when they're damaged, which could lead to better treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $243,000 |
| NIH project number | 3R35GM150506-02S1 |
| Project ID | NIH-11035481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing age-related diseases or conditions linked to lysosomal dysfunction, such as cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to lysosomal function or those who are not experiencing cellular stress may not benefit from this research.
What this research studies
This research investigates the role of lysosomes in cell health, particularly how they manage nutrient recycling and respond to cellular stress. It focuses on understanding lysosomal dysfunction, which is linked to aging and various diseases, including cardiovascular issues. The researchers are exploring a newly discovered pathway that helps lysosomes repair themselves quickly after damage, which could lead to better treatments for related diseases. By using advanced proteomic screening, they aim to identify key proteins involved in this repair process.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for diseases associated with lysosomal dysfunction, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding lysosomal repair mechanisms, but this specific approach is novel and untested.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Tan, Xiaojun — University of Pittsburgh at Pittsburgh
- Study coordinator: Tan, Xiaojun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.