Understanding how lung immune cells remember past infections to prevent pneumonia.
Lung Macrophage Memory Development and Responses in Secondary Pneumonia and Sepsis
This study is looking at how certain immune cells in your lungs remember past viral infections and how that might make you more likely to get pneumonia later, with the goal of finding new ways to help prevent this from happening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10894157 on NIH RePORTER |
What this research studies
This research investigates how lung macrophages, a type of immune cell, develop memory after viral infections, which can lead to increased risk of secondary bacterial pneumonia. The study aims to identify the molecular mechanisms that allow these cells to retain memory of past infections and respond more aggressively to subsequent bacterial threats. By using advanced genomic techniques, researchers will explore how these immune cells are reprogrammed during and after viral infections, potentially leading to new strategies for preventing pneumonia. This work is crucial for improving patient outcomes following viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently recovered from viral infections, particularly those at risk for developing secondary bacterial pneumonia.
Not a fit: Patients who have not experienced viral infections or those with chronic lung diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response to prevent secondary pneumonia in patients recovering from viral infections.
How similar studies have performed: Other research has shown promise in understanding immune memory, but this specific approach to lung macrophage memory is relatively novel and untested.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Mishra, Bibhuti Bhusan — University of Texas Hlth Science Center
- Study coordinator: Mishra, Bibhuti Bhusan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.