Understanding how lung cells regenerate after injury
Official title: Sources and Regulation of Epithelial Stem/Progenitor Cells in Alveolar Regeneration
Funded at Icahn School of Medicine at Mount Sinai · NIH-11019685 · Data updated 2026-11-12
This study is looking at how certain cells in the lungs help heal after serious injuries, like from the flu or certain treatments, and it hopes to find ways to improve lung function by understanding how these cells work, which could also apply to people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $248,996 |
| NIH project number | 5R00HL155785-05 |
| Project ID | NIH-11019685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who have experienced acute lung injuries.
✕Less likely to help
Patients with chronic lung conditions or those who have not experienced acute lung injuries may not benefit from this research.
What this research studies
This research investigates the sources and functions of epithelial stem and progenitor cells in the lungs, particularly after severe injuries like influenza or bleomycin exposure. It aims to identify how these cells respond to damage and contribute to lung repair, focusing on a specific type of airway progenitor cell that shows promise in improving lung function. By studying the mechanisms that activate these cells, the research seeks to clarify their role in recovery and whether similar processes occur in human lungs as observed in mice.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung regeneration and recovery after severe injuries.
How similar studies have gone: Previous studies have shown promise in understanding lung regeneration mechanisms, but this specific approach is novel and aims to clarify unanswered questions.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Kathiriya, Jaymin J — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kathiriya, Jaymin J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.