Understanding how LOX-1 helps the immune system during pneumonia
Official title: Establishing Mechanisms of LOX-1-Dependent Immune Regulation During Pneumonia
Funded at University of Iowa · NIH-11103650 · Data updated 2026-11-12
This study is looking at how a special receptor called LOX-1 helps the body fight pneumonia and heal the lungs afterward, and it's for anyone interested in understanding how we can improve treatments for pneumonia and similar illnesses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 22, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL159258-03 |
| Project ID | NIH-11103650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with pneumonia or acute respiratory distress syndrome (ARDS).
✕Less likely to help
Patients with chronic lung diseases unrelated to pneumonia may not benefit from this research.
What this research studies
This research investigates the role of a specific receptor, LOX-1, in regulating the immune response during pneumonia. It aims to understand how LOX-1 helps the body not only fight off the infection but also heal the lung tissue afterward. The study will involve analyzing immune cells in the lungs of patients and animal models to see how LOX-1 influences inflammation and recovery. By uncovering these mechanisms, the research hopes to provide insights into better treatments for pneumonia and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance recovery from pneumonia and reduce lung damage.
How similar studies have gone: Previous research has shown promising results in understanding immune regulation during pneumonia, but the specific role of LOX-1 in this context is still being explored.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Korkmaz, Filiz — University of Iowa
- Study coordinator: Korkmaz, Filiz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.