Understanding how L-2-hydroxyglutarate affects immune cell development and function
Official title: Investigating the role of L-2-hydroxyglutarate in helper T cell differentiation and function
Funded at Sloan-Kettering Inst Can Research · NIH-10998452 · Data updated 2026-11-12
This study is looking at how a substance called L-2-hydroxyglutarate affects the development and function of helper T cells, which are important for our immune system, to see if it can help us understand and treat autoimmune diseases and certain cancers like acute myeloid leukemia.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 5, 2024 |
| Project end | August 4, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI181502-01A1 |
| Project ID | NIH-10998452 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases or those diagnosed with acute myeloid leukemia.
✕Less likely to help
Patients with conditions unrelated to immune function or metabolic disorders may not receive any benefit from this research.
What this research studies
This research investigates the role of L-2-hydroxyglutarate in the differentiation and function of helper T cells, which are crucial for immune responses. The study aims to explore how metabolic pathways, particularly those involving L-2-hydroxyglutarate, influence the development of these immune cells. By examining the effects of this metabolite on T cell differentiation, the research seeks to clarify its potential implications for autoimmune diseases and cancers like acute myeloid leukemia. Patients may benefit from insights gained about immune function and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and improving immune responses in cancer patients.
How similar studies have gone: Previous research has shown that metabolic pathways significantly influence immune cell function, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Mcnamara, Thomas Francis — Sloan-Kettering Inst Can Research
- Study coordinator: Mcnamara, Thomas Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.