Understanding how knee osteoarthritis progresses using MRI scans
Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographs
This study is looking at how certain changes in knee structure seen on MRI scans can help us understand why some people with knee osteoarthritis experience faster worsening of their condition, with the goal of improving treatments for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10859277 on NIH RePORTER |
What this research studies
This research investigates the factors that contribute to the rapid progression of knee osteoarthritis (OA) by analyzing structural features visible on MRI scans. The study aims to identify specific patterns of knee pain and their relationship with various MRI-defined structural abnormalities over time. By leveraging advanced imaging techniques and machine learning, the researchers hope to enhance the screening process for clinical trials, ultimately leading to better treatment options for patients suffering from knee OA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with knee osteoarthritis who experience varying degrees of knee pain.
Not a fit: Patients without a diagnosis of knee osteoarthritis or those with other unrelated joint conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening methods for clinical trials, resulting in more effective treatments for knee osteoarthritis.
How similar studies have performed: Previous studies have shown promise in using MRI and machine learning to understand knee osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Kwoh, C Kent — University of Arizona
- Study coordinator: Kwoh, C Kent
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.