Understanding how Kif2c affects cell structure during early embryo development
Official title: Investigating the role of Kif2c in transforming the microtubule cytoskeleton at the oocyte-to-embryo transition
Funded at University of Pennsylvania · NIH-11164099 · Data updated 2026-11-12
This study is looking at how a gene called Kif2c helps with the changes in cell structure that happen when an egg turns into an embryo, using zebrafish to see what happens when this gene doesn't work right, which could help us understand problems with cell division and development.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $49,538 |
| NIH project number | 1F31HD116433-01A1 |
| Project ID | NIH-11164099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or families with a history of reproductive issues or genetic conditions related to chromosome abnormalities.
✕Less likely to help
Patients who do not have concerns related to reproductive health or chromosome abnormalities may not benefit from this research.
What this research studies
This research investigates the role of the Kif2c gene in the transformation of the microtubule cytoskeleton during the critical transition from oocyte to embryo. By studying zebrafish models, the research aims to uncover how disruptions in Kif2c can lead to issues in chromosome movement and cell division. The approach involves examining maternal-effect mutants to understand the specific control of microtubule organization during oocyte maturation and egg activation. This could provide insights into the mechanisms that ensure proper embryonic development.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of developmental disorders related to chromosome misalignment and aneuploidy.
How similar studies have gone: Previous studies have shown success in understanding microtubule dynamics and chromosome behavior in similar biological models, indicating that this approach has a foundation in established research.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Marvin, Allison — University of Pennsylvania
- Study coordinator: Marvin, Allison
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.