Understanding how intestinal stem cells communicate to control gut function
Official title: Control of Intestinal Epithelial Function through Lymphatic-Intestinal Stem Cell Communication
Funded at Sloan-Kettering Inst Can Research · NIH-11042767 · Data updated 2026-11-12
This study is looking at how the tiny cells in your gut talk to their surroundings to keep your digestive system healthy and how they react when things go wrong, like in inflammatory bowel disease (IBD), with the hope of finding new ways to help people with gut issues.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $167,617 |
| NIH project number | 5K08DK132518-04 |
| Project ID | NIH-11042767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with inflammatory bowel diseases or those experiencing gut-related health issues.
✕Less likely to help
Patients with non-intestinal related health conditions or those not suffering from any gastrointestinal disorders may not benefit from this research.
What this research studies
This research investigates the communication between intestinal stem cells and their surrounding environment to understand how they maintain gut health and respond to diseases like inflammatory bowel disease (IBD). The principal investigator, Dr. Rachel Niec, will utilize advanced techniques such as microscopy and transcriptomics to explore how signals from the intestinal niche influence stem cell behavior. By studying these interactions, the research aims to uncover mechanisms that could lead to new treatments for gut-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients suffering from inflammatory bowel diseases and other intestinal disorders.
How similar studies have gone: Previous research has shown promising results in understanding stem cell behavior in other contexts, suggesting that this approach may yield valuable insights into intestinal health.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Niec, Rachel E — Sloan-Kettering Inst Can Research
- Study coordinator: Niec, Rachel E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.