Understanding how integrins affect brain development and function
Official title: Integrin Functions in Shaping Cortical Circuits
Funded at James Madison University · NIH-10831104 · Data updated 2026-11-12
This study is looking at how a specific protein called integrin beta 3 affects brain development and function, which could help us understand and improve treatments for conditions like autism.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James Madison University NIH-funded |
| Lab location | 1 site (Harrisonburg, United States) |
| Project start | May 1, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $210,600 |
| NIH project number | 5K01NS107723-05 |
| Project ID | NIH-10831104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are individuals diagnosed with autism spectrum disorder, especially those in early developmental stages.
✕Less likely to help
Patients with neurodevelopmental disorders unrelated to integrin functions or those outside the autism spectrum may not receive benefit from this research.
What this research studies
This research investigates the role of integrins, specifically integrin beta 3, in the development and function of the cerebral cortex, which is crucial for diagnosing and treating neurodevelopmental disorders like autism. The approach involves studying the anatomical, physiological, and behavioral impacts of these proteins on brain circuitry in living organisms. By utilizing advanced techniques, the research aims to clarify how these cell adhesion molecules influence brain development and connectivity, potentially leading to new insights into autism spectrum disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for neurodevelopmental disorders, particularly autism.
How similar studies have gone: Previous research has shown promising results in understanding the role of cell adhesion molecules in neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
James Madison University
Harrisonburg, United States Active
Researchers
- Principal investigator: Vidal, George — James Madison University
- Study coordinator: Vidal, George
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.