NIH-funded research R01 grant

Understanding how aging affects balance through vestibular reflexes

Official title: Nonlinearities in Human Vestibular Reflexes

Funded at James Madison University · NIH-10858557 · Data updated 2026-11-12

This study is looking at how getting older affects balance by checking how well the inner ear helps with stability, and it's designed for adults who want to understand more about balance issues and improve their overall stability.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJames Madison University
NIH-funded
Lab location1 site (Harrisonburg, United States)
Project startAugust 12, 2024
Project endJuly 31, 2029
Funding year2024
Award (this year)$414,011
NIH project number1R01DC021684-01
Project IDNIH-10858557 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults aged 21 and older who experience balance issues or dizziness.

Less likely to help

Patients who are under 21 years old or do not have balance disorders may not benefit from this research.

What this research studies

This research investigates how age-related changes in the vestibular system impact balance in adults. Using advanced electrophysiological techniques, the study aims to identify nonlinear responses in vestibular evoked myogenic potentials (VEMPs), which are crucial for detecting balance-related signals. By examining these responses in relation to aging, the research seeks to enhance clinical diagnosis and rehabilitation strategies for individuals experiencing balance disorders. Participants will undergo assessments to evaluate their vestibular function and balance capabilities.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for balance disorders in older adults.

How similar studies have gone: While the study of vestibular reflexes is established, the specific focus on nonlinearities in human responses is a novel approach that has not been extensively tested.

Where this research is happening

  • James Madison University
    Harrisonburg, United States
    Active

Researchers

  • Principal investigator: Piker, Erin G — James Madison University
  • Study coordinator: Piker, Erin G

Related research

Other NIH-funded projects on the same topics.

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  • How aging changes balance signals from the inner ear

    This project looks at new recordings of inner-ear reflex signals in adults to understand how aging changes balance.

    NIH research James Madison University · Harrisonburg, United States · NIH-11167774

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  • Understanding how integrins affect brain development and function

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  • Investigating how certain enzymes in mitochondria regulate energy production.

    This study is looking at how a special enzyme in our cells helps produce energy and can create harmful substances, which is important for understanding conditions like cancer and heart disease, and it aims to find new ways to treat these issues.

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About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.