Investigating how certain enzymes in mitochondria regulate energy production.
Official title: Administrative Supplement to Purchase a High-Performance Computing System
Funded at James Madison University · NIH-10796074 · Data updated 2026-11-12
This study is looking at how a special enzyme in our cells helps produce energy and can create harmful substances, which is important for understanding conditions like cancer and heart disease, and it aims to find new ways to treat these issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James Madison University NIH-funded |
| Lab location | 1 site (Harrisonburg, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $99,875 |
| NIH project number | 3R15GM141975-01S1 |
| Project ID | NIH-10796074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers or cardiovascular diseases who may benefit from advancements in mitochondrial-targeted therapies.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those not affected by cancer or cardiovascular diseases may not receive any benefit from this research.
What this research studies
This research focuses on understanding the mechanisms by which a key enzyme in mitochondria, known as the bc1 complex, regulates energy production and the generation of reactive oxygen species. By combining computational modeling and experimental techniques, the researchers aim to explore how specific modifications and lipid compositions affect the enzyme's function. Patients may benefit from insights gained about these processes, particularly in relation to cancers and cardiovascular diseases, as the findings could lead to new therapeutic strategies. The study will involve detailed molecular dynamics simulations and experimental validation to uncover these regulatory mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers and cardiovascular diseases by improving our understanding of mitochondrial function.
How similar studies have gone: Other research has shown promising results in understanding mitochondrial function and its implications for various diseases, suggesting that this approach has potential for success.
Where this research is happening
-
James Madison University
Harrisonburg, United States Active
Researchers
- Principal investigator: Kokhan, Oleksandr — James Madison University
- Study coordinator: Kokhan, Oleksandr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.