Understanding how inner nose tissues go wrong in chronic nasal polyps
Official title: Epithelial and Fibroblast Dysfunction in Chronic Rhinosinusitis with Nasal Polyps
Funded at Brigham and Women's Hospital · NIH-11352000 · Data updated 2026-11-12
Aimed at people with chronic rhinosinusitis with nasal polyps, this study looks at how tissue and cell signals drive inflammation and tissue changes in the nose.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 15, 2011 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $450,185 |
| NIH project number | 2U19AI095219-16 |
| Project ID | NIH-11352000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with chronic rhinosinusitis with nasal polyps, including those with aspirin-exacerbated respiratory disease, who can provide tissue samples.
✕Less likely to help
Patients without CRSwNP or those unable to provide tissue samples may not directly benefit.
What this research studies
This project investigates how abnormal cell signaling in the nasal lining and surrounding tissue leads to ongoing inflammation and tissue remodeling in CRSwNP. Researchers will use samples from patients to study mTORC1 signaling, epithelial repair, and ECM remodeling, and will test how these pathways affect epithelial growth and fibroblast activity. They will also explore how deposited ECM components activate immune cells like mast cells and macrophages, using human-derived cells and advanced molecular techniques. The goal is to map the cellular conversations that sustain disease and identify points where therapies could interrupt this process.
Why it matters
Potential benefit: If successful, the work could point to new targets for therapies to reduce nasal inflammation and polyp growth in CRSwNP.
How similar studies have gone: Previous work has shown that mTORC1 signaling and ECM interactions influence inflammatory tissue remodeling, making this a promising but still exploratory approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Barrett, Nora Amanda — Brigham and Women's Hospital
- Study coordinator: Barrett, Nora Amanda
Related research
Other NIH-funded projects on the same topics.
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Metabolic and Immunologic Biomarkers in Chronic Rhinosinusitis with Nasal Polyps
This study tests whether metabolic and immune markers in nasal tissue and blood differ between people with nasal polyps and those without, to help understand CRSwNP and find potential diagnostic clues.
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GSK5784283 as add-on therapy for chronic rhinosinusitis with nasal polyps
This study tests whether GSK5784283 added to standard care can help adults with chronic rhinosinusitis with nasal polyps feel better and have fewer symptoms.
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GSK5784283 as add-on maintenance therapy for nasal polyps in chronic rhinosinusitis
This study tests whether adding GSK5784283 (Felcorekibart) to standard care helps people with chronic rhinosinusitis with nasal polyps.
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Triamcinolone-loaded nanocapsules after endoscopic nasal surgery
This trial tests whether a triamcinolone acetonide–loaded nanocapsule spray is better than saline irrigation for healing after endoscopic nasal surgery in adults with chronic rhinosinusitis and nasal polyps.
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Depemokimab monotherapy for chronic rhinosinusitis with nasal polyps in Japanese adults
This study tests depemokimab alone (without intranasal corticosteroids) in adults with chronic rhinosinusitis with nasal polyps in Japan.
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Stopping mepolizumab or dupilumab to see if nasal polyps stay in complete remission.
This trial will test whether adults with well-controlled nasal polyps who have been on mepolizumab or dupilumab can safely stop the biologic and remain symptom-free.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.