Understanding how immune cells move and cause inflammation
Neutrophil migration and inflammation
This work explores how certain immune cells, called neutrophils, move through the body and contribute to inflammation, which is important for conditions like heart disease and autoimmune disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-11129910 on NIH RePORTER |
What this research studies
Inflammation is a natural process that helps our bodies heal from injury and infection, but it can also cause harm in conditions like heart disease and autoimmune diseases. This project focuses on neutrophils, key immune cells that play a big role in both fighting infection and causing tissue damage. Researchers are working to better understand how these neutrophils move and behave, using zebrafish as a model to discover new genes that control their movement. Findings from the zebrafish are then checked in human cells to ensure relevance to people. The goal is to find new ways to manage inflammation by targeting these neutrophil movements.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future studies building on this work may seek individuals with inflammatory conditions, atherosclerotic cardiovascular disease, or autoimmune diseases.
Not a fit: Patients without inflammation-related conditions or those seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent and treat a wide range of inflammation-related diseases, including atherosclerotic cardiovascular disease and autoimmune conditions.
How similar studies have performed: While the specific approach of using microRNAs to regulate neutrophil migration in this context is novel, other studies have shown success in understanding immune cell behavior and inflammation pathways.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Deng, Qing — Purdue University
- Study coordinator: Deng, Qing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.