Understanding how immune cells develop and function in the body
Official title: Molecular regulation of lymphoid lineage priming in steady state and regeneration
Funded at Boston Children's Hospital · NIH-10865601 · Data updated 2026-11-12
This study is looking at how your body makes important immune cells called T and B lymphocytes, especially when you're recovering from things like a bone marrow transplant, to find out why some people have fewer of these cells and how we can help boost their immune system.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $148,446 |
| NIH project number | 1K99HL173553-01 |
| Project ID | NIH-10865601 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have undergone hematopoietic stem cell transplantation or those with conditions affecting their immune system.
✕Less likely to help
Patients with fully functional immune systems or those not experiencing any hematopoietic issues may not benefit from this research.
What this research studies
This research investigates the mechanisms that control the development of T and B lymphocytes, which are crucial for a healthy immune system. It focuses on how these immune cells are produced from hematopoietic stem cells, especially during times of stress or recovery, such as after a bone marrow transplant. By studying the genetic and cellular factors involved, the research aims to uncover why some individuals have reduced immune cell output and how this can be improved. This knowledge could lead to better therapies for patients with weakened immune systems.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with compromised immune systems, enhancing their ability to fight infections and recover from illnesses.
How similar studies have gone: Previous research has shown promising results in understanding immune cell development, but this specific approach to studying lymphoid lineage regulation is relatively novel.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Mesquitta, Walatta-Tseyon Waziru — Boston Children's Hospital
- Study coordinator: Mesquitta, Walatta-Tseyon Waziru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.