Understanding how human thyroid cells develop and function
Thyroid Follicular Cell Signaling and Development in Humans
This study is exploring how to grow thyroid cells from special stem cells to learn more about congenital hypothyroidism, a condition that affects hormone production in the thyroid, with the hope of finding new ways to treat it in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10849930 on NIH RePORTER |
What this research studies
This research investigates the development of thyroid follicular cells from human induced pluripotent stem cells (iPSCs) to better understand congenital hypothyroidism, a condition affecting hormone production from the thyroid gland. The researchers will use innovative techniques to trace the lineage of these cells and ensure that their development mimics natural processes. By identifying key factors involved in this development, the study aims to pave the way for potential genetic editing and cellular therapies that could treat congenital hypothyroidism effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital hypothyroidism or those at risk of developing this condition due to genetic factors.
Not a fit: Patients without congenital hypothyroidism or related thyroid disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for congenital hypothyroidism, potentially reducing the need for lifelong hormone replacement therapy.
How similar studies have performed: Previous research has shown promise in using stem cells for thyroid cell development, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Hollenberg, Anthony N — Boston University Medical Campus
- Study coordinator: Hollenberg, Anthony N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.