IL-6 signaling and lung injury after TB and HIV co-infection
Official title: Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV
Funded at Boston University Medical Campus · NIH-11604269 · Data updated 2026-11-12
This project looks at how a common immune signal called IL-6 relates to lung injury after TB treatment, especially in people who also have HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $94,873 |
| NIH project number | 3R01AI184179-03S1 |
| Project ID | NIH-11604269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) with drug-sensitive TB, including a comparison group of HIV-positive individuals with TB.
✕Less likely to help
People without TB or those not enrolled in the TB/HIV cohorts may not benefit.
What this research studies
The study will follow adults with drug-sensitive TB in India, including a matched group with HIV, to see how lung damage develops after TB treatment ends. It will measure IL-6 related pathways and related biomarkers to understand who is at higher risk for long-term lung problems. The research is done across multiple sites in the RePORT-India TB consortium, aiming to capture real-world outcomes in a high-burden setting. Results could point to strategies to prevent or lessen lasting lung injury in TB patients, including those with HIV.
Why it matters
Potential benefit: If successful, the work could lead to interventions that reduce long-term lung disability after TB, especially for people with HIV.
How similar studies have gone: Previous studies have shown IL-6 pathways are involved in inflammatory lung injury, but this project tests their role specifically in post-TB lung disease with HIV co-infection.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Gupte, Akshay Nitin — Boston University Medical Campus
- Study coordinator: Gupte, Akshay Nitin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.