Understanding how human proteins control gene expression
Official title: Translational Control by Human Pumilio Proteins
Funded at University of Minnesota · NIH-11094353 · Data updated 2026-11-12
This study is looking at how two proteins, PUM1 and PUM2, help control the way our genes work, which could affect conditions like infertility and cancer, and it aims to understand how they influence the process of turning genes into proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 18, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $171,898 |
| NIH project number | 3R01GM150468-02S1 |
| Project ID | NIH-11094353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing infertility or those affected by cancers linked to gene regulation dysfunction.
✕Less likely to help
Patients with conditions unrelated to gene regulation or those not experiencing infertility or cancers may not benefit from this research.
What this research studies
This research investigates the role of human RNA-binding proteins, PUM1 and PUM2, in regulating gene expression and their impact on various diseases, including infertility and cancers. The researchers aim to uncover how these proteins influence the transition from gene to mRNA to protein, focusing on their ability to bind to specific RNA sequences. By identifying the full range of genes regulated by PUM1 and PUM2, the study seeks to provide insights into their functions in both normal development and disease processes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like infertility and certain cancers by targeting the mechanisms of gene regulation.
How similar studies have gone: Previous research has shown that understanding RNA-binding proteins can lead to significant advancements in treating related diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Goldstrohm, Aaron Charles — University of Minnesota
- Study coordinator: Goldstrohm, Aaron Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.