Understanding How Human P450 Enzymes Work
Official title: Structure-Function Studies of the Human Cytochrome P450 27 Family
Funded at Appalachian State University · NIH-11136301 · Data updated 2026-11-12
This research aims to understand how a specific group of human enzymes, called P450 27 family, function to help develop new and safer treatments for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Appalachian State University NIH-funded |
| Lab location | 1 site (Boone, United States) |
| Project start | September 5, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $345,000 |
| NIH project number | 5R35GM147276-04 |
| Project ID | NIH-11136301 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who might benefit in the future are those with conditions where P450 27 family enzymes play a role, such as certain cancers or disorders related to steroid hormones, vitamin D, or retinoid metabolism.
✕Less likely to help
Patients whose conditions are not related to the function of the P450 27 family enzymes may not directly benefit from this specific line of research.
What this research studies
Our bodies have special enzymes called P450s that process important substances like hormones, vitamins, and even medicines or harmful chemicals. This project focuses on a particular group, the P450 27 family, which plays a role in how our bodies handle vitamin D, cholesterol, and retinoids. Depending on their activity, these enzymes can have good or bad effects on our health. By learning exactly how these enzymes are structured and how they interact with other proteins, we hope to find ways to either boost or slow down their activity. This knowledge could lead to new, more targeted medications that work better and have fewer side effects.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more effective, and safer drug therapies for conditions influenced by these P450 enzymes, including those related to cancer-causing agents and hormone imbalances.
How similar studies have gone: Previous studies on P450 enzymes have already led to significant advancements in medicine, suggesting a strong foundation for this approach.
Where this research is happening
-
Appalachian State University
Boone, United States Active
Researchers
- Principal investigator: Reddish, Michael Jerrell — Appalachian State University
- Study coordinator: Reddish, Michael Jerrell
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.