Identifying gene enhancers that help nerves regenerate in the central nervous system.
Official title: Axon Regeneration-Associated Gene Enhancers Promoting Successful CNS Nerve Regeneration
Funded at Appalachian State University · NIH-10873691 · Data updated 2026-11-12
This study is looking at how certain DNA sequences can help nerves heal better after injuries, using zebrafish as a model, to find ways to improve treatments for people with central nervous system damage.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Appalachian State University NIH-funded |
| Lab location | 1 site (Boone, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $69,000 |
| NIH project number | 5R03NS128755-02 |
| Project ID | NIH-10873691 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with central nervous system injuries or disorders, particularly those who are 21 years or older.
✕Less likely to help
Patients with non-CNS related injuries or conditions may not benefit from this research.
What this research studies
This research focuses on discovering specific DNA sequences, known as enhancers, that can control gene expression to promote successful nerve regeneration in the central nervous system (CNS). By using zebrafish models, which naturally regenerate their nerves, the study aims to understand how these enhancers can be applied to improve gene therapy approaches for CNS injuries. The goal is to develop a more precise method of gene therapy that minimizes toxicity and enhances the body's ability to heal itself after nerve damage. This could lead to better treatments for conditions affecting the CNS.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with CNS injuries, improving their recovery and quality of life.
How similar studies have gone: Previous research has shown success in using zebrafish models to identify gene enhancers that promote nerve regeneration, indicating a promising approach.
Where this research is happening
-
Appalachian State University
Boone, United States Active
Researchers
- Principal investigator: Udvadia, Ava J — Appalachian State University
- Study coordinator: Udvadia, Ava J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.