Understanding how estrogen affects sleep-regulating neurons
Official title: Examining Estrogenic Regulation of Orexin Neurons to Reveal Subpopulations
Funded at Appalachian State University · NIH-11124344 · Data updated 2026-11-12
This study is looking at how estrogen affects certain brain cells that help control sleep and energy, especially in women after menopause, to better understand why some may experience sleep problems and related issues.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Appalachian State University NIH-funded |
| Lab location | 1 site (Boone, United States) |
| Project start | April 5, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $504,705 |
| NIH project number | 1R15DK140842-01A1 |
| Project ID | NIH-11124344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women experiencing sleep disturbances or anxiety, especially those who are post-menopausal.
✕Less likely to help
Patients who are not female or who do not have sleep-related issues may not benefit from this research.
What this research studies
This research investigates the role of estrogen in regulating orexin neurons, which are crucial for controlling sleep, arousal, and energy balance. The study aims to identify different subpopulations of these neurons and how they may be affected by hormonal changes, particularly after menopause. By examining the variations in these neurons, the research seeks to uncover mechanisms that could lead to sleep disturbances and other related disorders, especially in women. The approach involves analyzing the signaling pathways and responses of these neurons to estrogen levels.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sleep disorders and related conditions in women, particularly those experiencing hormonal changes.
How similar studies have gone: Previous research has shown that hormonal regulation of neuronal populations can significantly impact sleep and mood disorders, suggesting potential for success in this area.
Where this research is happening
-
Appalachian State University
Boone, United States Active
Researchers
- Principal investigator: Stincic, Todd Lynn — Appalachian State University
- Study coordinator: Stincic, Todd Lynn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.