Understanding how HIV-1 splice variants function and interact with proteins
Official title: Deciphering HIV-1 alternatively spliced transcript function with HyPR-MS
Funded at University of Wisconsin-Madison · NIH-11035850 · Data updated 2026-11-12
This study is looking at how different versions of the HIV virus interact with proteins in the body, which could help us understand how the virus grows and spreads, and it aims to find better treatments for people living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $532,733 |
| NIH project number | 1R56AI170578-01A1 |
| Project ID | NIH-11035850 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young individuals (ages 0-21) living with HIV/AIDS.
✕Less likely to help
Patients who are not infected with HIV or are outside the age range of 0-21 may not benefit from this research.
What this research studies
This research investigates the complex interactions between HIV-1 splice variants and proteins that influence the virus's life cycle. By developing advanced tools like HyPR-MS and SV-FISH, the team aims to explore how these splice variants affect gene expression and viral replication. The study focuses on understanding the roles of over 40 splice variants, which are crucial for the virus's ability to thrive. Patients may benefit from insights gained about HIV-1 that could lead to improved treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating HIV-1 infections by targeting specific splice variants.
How similar studies have gone: Previous research has shown promise in understanding RNA-protein interactions in viral infections, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Sherer, Nathan M — University of Wisconsin-Madison
- Study coordinator: Sherer, Nathan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.