Understanding how heparanase affects cell environments
Official title: Exploring the precise role of heparanase via small molecule probes
Funded at University of Florida · NIH-11010941 · Data updated 2026-11-12
This study is looking at how a special enzyme called heparanase affects the support structure around our cells, which is important for how cells work and talk to each other, and it hopes to find better ways to treat conditions like cancer and inflammation by understanding these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 11, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $444,830 |
| NIH project number | 1R35GM156219-01 |
| Project ID | NIH-11010941 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to cancer, angiogenesis, or inflammation.
✕Less likely to help
Patients with conditions unrelated to ECM remodeling or heparanase activity may not benefit from this research.
What this research studies
This research investigates the role of heparanase, an enzyme that modifies the extracellular matrix (ECM) surrounding cells, which is crucial for cell function and communication. By developing specialized molecular probes, the research aims to explore how heparanase influences ECM remodeling and its implications in conditions like cancer and inflammation. Patients may benefit from insights gained about how to better target therapies that involve ECM interactions and cellular signaling.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cancers and other diseases by targeting the mechanisms of ECM remodeling.
How similar studies have gone: Previous research has shown promising results in understanding ECM dynamics and targeting similar pathways in cancer treatment.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Cui, Lina — University of Florida
- Study coordinator: Cui, Lina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.