Understanding how heart cells control protein disposal to prevent heart failure
Official title: Cardiac Pathophysiology of Proteasome Phosphoregulation
Funded at University of South Dakota · NIH-11248064 · Data updated 2026-11-12
A research project from the University of South Dakota aims to learn how the heart’s protein disposal system works during ischemic heart disease to help prevent heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Dakota NIH-funded |
| Lab location | 1 site (Vermillion, United States) |
| Project start | September 1, 2020 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $686,064 |
| NIH project number | 5R01HL153614-06 |
| Project ID | NIH-11248064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have or are at risk for ischemic heart disease, heart attack, or heart failure may benefit from future therapies informed by this research.
✕Less likely to help
Patients without ischemic heart disease or those not connected to future proteasome-targeted therapies may not experience direct benefits.
What this research studies
This project studies how the heart’s proteasome, a protein-degrading machine, is regulated during and after a heart attack. By uncovering what goes wrong with protein disposal in heart muscle cells, researchers hope to identify new ways to keep the heart healthy after injury. The work combines molecular studies with models of heart disease to connect basic biology to potential therapies. If successful, the findings could point toward strategies that support heart recovery and delay heart failure.
Why it matters
Potential benefit: If successful, the research could reveal targets to improve heart cell cleanup after a heart attack, potentially reducing progression to heart failure.
How similar studies have gone: Previous work suggests proteasome function is linked to heart disease progression, but translating this into therapies remains an emerging area.
Where this research is happening
-
University of South Dakota
Vermillion, United States Active
Researchers
- Principal investigator: Wang, Xuejun — University of South Dakota
- Study coordinator: Wang, Xuejun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.