Targeting HIV reservoirs in the brain to improve treatment outcomes
Official title: Targeting HIV Myeloid Reservoirs in the CNS by IAP and TREM1 Inhibition
Funded at University of South Dakota · NIH-11081715 · Data updated 2026-11-12
This study is looking for new ways to help people with HIV by targeting hidden spots in the brain where the virus can still hide, even when they're on treatment, and it focuses on understanding how certain proteins can help in this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Dakota NIH-funded |
| Lab location | 1 site (Vermillion, United States) |
| Project start | December 1, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $317,688 |
| NIH project number | 5R01MH128021-05 |
| Project ID | NIH-11081715 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but still have detectable viral reservoirs.
✕Less likely to help
Patients who are not on antiretroviral therapy or those without detectable viral reservoirs may not benefit from this research.
What this research studies
This research focuses on finding new ways to eliminate HIV from persistent reservoirs in the central nervous system (CNS) of individuals undergoing antiretroviral therapy (ART). It aims to investigate the roles of specific proteins, IAP and TREM1, in targeting these reservoirs, which include macrophages and microglia that can harbor the virus despite treatment. By understanding how to effectively disrupt these reservoirs, the research seeks to enhance the effectiveness of current HIV treatments and potentially lead to a functional cure.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that eliminate HIV reservoirs, reducing the need for lifelong ART and the associated challenges.
How similar studies have gone: Other research has shown promise in targeting HIV reservoirs, but this specific approach focusing on CNS reservoirs is relatively novel.
Where this research is happening
-
University of South Dakota
Vermillion, United States Active
Researchers
- Principal investigator: Campbell, Grant R — University of South Dakota
- Study coordinator: Campbell, Grant R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.