Understanding how glycoRNAs function on cell surfaces
Official title: Mechanisms and functions of cell surface glycoRNAs
Funded at Boston Children's Hospital · NIH-11124887 · Data updated 2026-11-12
This study is exploring a new type of molecule called glycoRNAs that help cells communicate with each other, and it aims to find out how they work, which could lead to better ways to diagnose and treat diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 14, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $442,500 |
| NIH project number | 5R35GM151157-03 |
| Project ID | NIH-11124887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve cell signaling and communication, which may include autoimmune diseases or cancers.
✕Less likely to help
Patients with conditions unrelated to cell surface interactions or those who do not have a significant immune response may not benefit from this research.
What this research studies
This research investigates the role of glycoRNAs, a new class of biomolecules that combine RNA and carbohydrates, on the surfaces of living cells. By developing methods to study these molecules, the research aims to uncover their functions in cell communication and signaling, which could lead to new diagnostic and therapeutic strategies. The project focuses on understanding how glycoRNAs interact with other cells and pathogens, potentially revealing new insights into cell biology and disease mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to innovative diagnostic tools and therapies that target cell surface interactions, improving treatment options for various diseases.
How similar studies have gone: While the study of glycoRNAs is relatively novel, previous research has shown promise in understanding the roles of RNA and glycans in cell biology, suggesting potential for success in this area.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Flynn, Ryan Alexander — Boston Children's Hospital
- Study coordinator: Flynn, Ryan Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.