Understanding how gliomas evolve and change over time
Official title: Decoding glioma evolution and progression by multi-dimensional single-cell profiling
Funded at University of Pennsylvania · NIH-10746909 · Data updated 2026-11-12
This study is looking at how brain cancer, called gliomas, changes over time by exploring the genetic changes in the cancer cells, which could help find better ways to treat it before the treatments stop working.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 2, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00CA263149-03 |
| Project ID | NIH-10746909 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with gliomas who are undergoing treatment or monitoring for disease progression.
✕Less likely to help
Patients with other types of brain tumors or those who are not currently diagnosed with gliomas may not benefit from this research.
What this research studies
This research investigates the evolution of gliomas, a type of brain cancer, by examining the genetic and epigenetic changes that occur as the disease progresses. Using advanced single-cell profiling techniques, the study aims to identify how these changes affect the behavior of cancer cells and their response to treatment. By mapping the distinct cellular states of gliomas and their drivers, the research seeks to uncover potential targets for intervention before they become ineffective. This approach could lead to more effective treatment strategies tailored to the evolving nature of gliomas.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with gliomas by identifying new targets for therapy.
How similar studies have gone: Other research has shown promise in understanding tumor evolution in various cancers, suggesting that this approach could yield valuable insights for gliomas as well.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Silverbush, Dana — University of Pennsylvania
- Study coordinator: Silverbush, Dana
Related research
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How RNA Splicing Might Shape Glioma Cell States and Therapy Response
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Predicting how gene therapy spreads in glioblastoma after surgery to improve treatment coverage
This project uses a gene therapy that helps radiation work better against glioblastoma and builds computer models to predict where the therapy reaches after surgical tumor removal.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.