Understanding how genetics affects T cell behavior in autoimmune diseases
Official title: Investigating Genetic and Epigenetic Control of T Cell Function in Autoimmunity
Funded at Benaroya Research Inst at Virginia Mason · NIH-10687531 · Data updated 2026-11-12
This study is looking at how our genes might affect the way T cells work in autoimmune diseases, which many people in the U.S. have, to help find new ways to understand and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 8, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,559,700 |
| NIH project number | 1DP2AI183504-01 |
| Project ID | NIH-10687531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases who are interested in understanding the genetic factors influencing their condition.
✕Less likely to help
Patients with autoimmune diseases that do not have a significant genetic component may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors that influence T cell function in autoimmune diseases, which affect millions of people in the U.S. The study aims to identify specific genetic variants that may contribute to the development and progression of these conditions. By using advanced methodologies, the researchers will analyze how these variants impact T cell behavior, particularly in response to self-antigens. This could lead to a better understanding of the mechanisms behind autoimmune diseases and potential new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune diseases by identifying new targets for therapy.
How similar studies have gone: Previous research has shown promise in understanding genetic influences on autoimmune diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Ray, John Philip — Benaroya Research Inst at Virginia Mason
- Study coordinator: Ray, John Philip
Related research
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T cells and the switch from pre-autoimmunity to autoimmune disease
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Genetic and epigenetic control of T cell function in autoimmune disease
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Immune Tolerance Network (ITN) for immune tolerance therapies across autoimmune and allergic diseases
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Immune tolerance research network for safer transplant and autoimmune therapies
A national effort tests new treatments that make the immune system tolerate transplanted organs and fight autoimmune and allergic diseases more safely.
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Immune Tolerance Network for allergy, autoimmunity, and transplantation
A large NIH program tests new immune-tolerance therapies to help people with autoimmune diseases, allergies, and transplant patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.