Understanding how genetic variations affect diseases at the cellular level
Official title: Decoding disease-critical genomic architecture using multimodal single-cell omics data
Funded at Sloan-Kettering Inst Can Research · NIH-11040203 · Data updated 2026-11-12
This study is looking at how our genes affect diseases by examining tiny bits of genetic information from different cells, and it aims to find new ways to treat patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $522,866 |
| NIH project number | 1R01HG014008-01 |
| Project ID | NIH-11040203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with complex diseases that have a genetic component, particularly those willing to provide genetic samples.
✕Less likely to help
Patients with purely environmental diseases or those without a genetic basis for their condition may not benefit from this research.
What this research studies
This research investigates the complex genetic architecture of diseases by analyzing single-cell omics data, which includes various types of genetic information from different tissues and cell types. By employing advanced statistical and machine learning techniques, the project aims to decode how specific genetic variants influence disease processes and identify critical genes and pathways involved in these conditions. Patients may benefit from insights that could lead to new drug targets and improved treatment strategies based on their unique genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for complex diseases by identifying key genetic factors involved.
How similar studies have gone: Previous research has shown promise in using multi-omics approaches to understand disease mechanisms, indicating that this methodology could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Dey, Kushal Kumar — Sloan-Kettering Inst Can Research
- Study coordinator: Dey, Kushal Kumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.