Understanding how genetic factors affect multiple diseases
Statistical methods for identifying pleiotropy between complex human traits
This study is looking at how specific genes can affect different health issues, like cancer and inflammation, to help create better treatments that are tailored to each person's unique genetic makeup.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10874524 on NIH RePORTER |
What this research studies
This research investigates how certain genetic variants can influence multiple human traits and diseases, including cancers and inflammatory conditions. By analyzing data from extensive genome-wide association studies, the researchers aim to develop new statistical methods to identify common genetic factors that contribute to these traits. This could help in understanding the biological mechanisms behind diseases and improve drug development by predicting potential side effects. Patients may benefit from insights that could lead to more personalized treatment approaches based on their genetic makeup.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with complex traits or diseases such as cancer, Crohn's disease, or coronary artery disease.
Not a fit: Patients with single-gene disorders or those not affected by the studied complex traits may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of multiple diseases by identifying shared genetic risk factors.
How similar studies have performed: Previous research has shown success in identifying genetic overlaps between traits, making this approach promising for further advancements.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Ray, Debashree — Johns Hopkins University
- Study coordinator: Ray, Debashree
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.