Understanding how genetic factors affect heart development and defects
Official title: Multi-Lineage Modulation of cardiac neural crest cells during cardiac development
Funded at University of Pittsburgh at Pittsburgh · NIH-11192955 · Data updated 2026-11-12
This study is looking at the genes that cause congenital heart disease (CHD) in hopes of understanding why some heart treatments don’t work as well for people with CHD, using mice to find out how certain proteins affect heart development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 24, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $506,984 |
| NIH project number | 1R56HL173608-01 |
| Project ID | NIH-11192955 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with congenital heart disease, particularly those experiencing heart failure.
✕Less likely to help
Patients with heart conditions unrelated to congenital heart disease may not benefit from this research.
What this research studies
This research investigates the genetic basis of congenital heart disease (CHD), which is the most common birth defect. By using a chemical mutagenesis approach in mice, the study aims to identify mutations that lead to heart malformations. The researchers focus on specific proteins involved in cardiac development and how their absence affects the formation of heart structures. This work could provide insights into why traditional heart failure treatments are less effective for patients with CHD compared to those with structurally normal hearts.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for patients with congenital heart disease.
How similar studies have gone: Previous research has shown success in identifying genetic factors contributing to congenital heart defects, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Lin, Jiuann-Huey Ivy — University of Pittsburgh at Pittsburgh
- Study coordinator: Lin, Jiuann-Huey Ivy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.